Mojtaba Akramian Fard; Amir Moghaddam Ahmadi; Fatemeh Ayyobi; Hasan Nakisa; Zahra Hadadian; Mohammad Shabani; Mohammadollah Tavakoli; Ali Shamsi zadeh
Volume 22, Issue 1 , March and April 2015, , Pages 36-44
Abstract
Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium ...
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Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium in a Parkinson’s diseases model induced by ICV injection of 6-hydroxydopamin in male rats.
Materials and Methods: In this experimental study, 60 male rats were allocated into 6 groups including Control, Parkinson’s and Parkinson’s groups which treated by different doses of extract. Parkinson’s was induced by i.c.v injection of 6-OHDA. Aqueous extract of Achillea millefolium (1.4 and 2.8 mg/kg) was gavaged by two ways including repeated gavage (14 days before and for 14 days after 6-OHDA injection) and acute gavage (once in day 13 after 6-OHDA injection). Parkinson’s was evaluated using Rotarod and Wire grasping tests on day 14 after 6-OHDA injection.
Results: The result of this study demonstrated that repeated gavage of Achillea millefolium extract improved motility and muscle tone following administration of 6-OHDA in rats (p
Ali Shmasi zadeh; GholamHossein Hasanshahi; Ali Rohbakhsh; Fatemeh Ayobi; Mahshid Tahmtan
Volume 19, Issue 4 , January and February 2013, , Pages 310-324
Abstract
Background: Transient global cerebral ischemia, which leads to the extensive neuronal damage in the brain, results in a deficit in learning and memory. We designed the present study to investigate the effect of exercise preconditioning on learning and spatial memory following transient cerebral ischemia ...
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Background: Transient global cerebral ischemia, which leads to the extensive neuronal damage in the brain, results in a deficit in learning and memory. We designed the present study to investigate the effect of exercise preconditioning on learning and spatial memory following transient cerebral ischemia in rat. Materials and methods: In this experimental study, 50 male wistar rats weighing 250-300g were randomly allocated into different groups. Exercise was done by treadmill and for inducing cerebral ischemia both common carotid arteries were occluded for 10 minutes. Memory was evaluated by use of a step-through passive avoidance task. Sensory motor deficites was assesed by adhesive removal test and for evaluating slip ratio we used ledge beam walking test. Reslults: One week after transient cerebral ischemia, response latency decreased in passive avoidance test. Also touch time, remove time and slip ratio were increased in these animals. Exercise preconditioning improved the measured indices in ischemic rats. Conclusion: Exercise preconditioning improved deficites in learning and memory and also sensory motor function following transient cerebral ischemia.